Kahit Puso'y Masugatan is about two women whose bond of sisterhood will be challenged when they fall for only one man.

Andrea (Iza Calzado) and Veronica (Andy Eigenmann) are two different women brought together by fate. In their childhood years, they will learn to love and care for each other like real sisters. The two are inseparable until unfortunate circumstances will set them apart.

Through time, Andrea grew up to be a patient but determined young lady who will do everything for her loved ones, while Veronica turned out to be possessive with her life. Thus, she will do everything she can in her power to get what she wants, including the man she truly loves.
When their paths meet again after so many years, the bonds of sisterhood they used to share will be put to test as they fall in love with the same man, Rafael (Jake Cuenca).

As if things weren’t complicated enough as it is, Rafael faces a dilemma of his own as his wealthy dad, Miguel (Gabby Concepcion), falls for Andrea and even asks her hand in marriage. How will Andrea and Veronica fix their relationship as sisters? Will Andrea let go of Rafael to give way for her little sister Veronica? Will Rafael give Veronica a chance after finding out about his dad’s feelings for Andrea? Can Miguel risk destroying his bond with his very own son for the woman who taught him how to love again?

Under the direction of blockbuster director and master story teller Wenn Deramas, 'Kahit Puso’y Masugatan' marks the first ever teleserye of world-class actress Iza Calzado as a Kapamilya as well as the anticipated television comeback of heiress of drama Andi Eigenmann.

Also included in the powerhouse cast are veteran actors Jacklyn Jose, Malou De Guzman, Mylene Dizon, Assunta De Rossi, Cris Villanueva, DJ Durano, Mickey Ferriols, and Barbara Perez.