Based on the komiks creation of Jim Fernandez and Ernie Santiago and the 1970s film by Joey Gosiengfiao, Kambal Sa Uma tells the story of Ella (Melissa Ricks) and Vira (Shaina Magdayao), twin sisters who have some of the physical features of a rodent. When she was still a baby, Vira was given away by her mother Milagros (Rio Locsion) and ended up in the care of a rich couple in the city. Meanwhile, Ella remained with her mother and lived in the mountains away from persecution of people. Through a dramatic course of events, Ella and Vira will cross paths and their differences will lead to a bitter clash. What will happen once they discover their real identities? Will love prevail over hate?