Based on the komiks story by Rod Santiago, Agua Bendita follows the story of twin sisters, one is normal while one is born with a physical defect. Agua will struggle to find meaning in her life as she deals with her unexplainable physical condition. Meanwhile, in spite being born normal, Bendita will grow up insecure toward her twin sister. Agua and Bendita will become bitter rivals, until through a mysterious stroke of fate their situations will be reversed. Is their a way to cure the hatred between the sisters?