Bea Alonzo as Beatriz Pengson– Her intellectual capabilities and excellent organizational skills make her the perfect secretary for any top brass executive. The problem lies in her hideous looks which has always been a butt of jokes amongst her officemates. Yet not even such harsh treatment can deter her from achieving her goals and from being a nice girl towards other people.
	John Lloyd Cruz as Armando Solis – He is the epitome of a sophisticated and adventurous bachelor who remains a certified ladies’ man despite his soon-to-be-married status with his possessive girlfriend, Marcella. But the truth is that Armando has no choice but to give in to all her demands because her family happens to own the company where he works for.
	Ruffa Guitierez as Daniella – As the SVP of the ad agency owned by her family, it is her job to make sure that everything is under control in Eco Moda Manila. Her distrust towards Armando’s capabilities, however, often creates a rift between them. Knowing that he’s the fiancé of her younger sister only intensifies her belief that he’s nothing but a first-class gigolo.
	Vhong Navarro as Nicholas Mora – One can easily single him out in a crowd because of his attention-getting baduy outfit: high-waist pants, checkered polo shirt, and suspenders. Coupled with his weird personality, Nicholas is indeed the exact male counterpart of his best friend Betty La Fea. It is his fervent wish to win the heart of his dream girl Patricia.
	Megan Young as Marcella – For someone who’s born with a silver spoon on her mouth, Marcella is used to getting everything she wants. As a result, her boyfriend suffers the most because of her domineering attitude similar to that of Daniella. Since she’s aware of his womanizing ways, she keeps him under her beck and call at all times.
	Ai Ai delas Alas as Julia Pengson – She plans to work as a domestic helper in London to provide a better life for her family. But her children eventually persuade her to stay especially when Betty gets her first job in Eco Moda.
	Ronaldo Valdez as Hermes Pengson – As a father, he believes that his daughter can be whoever she wants to be because she’s an intelligent young lady. He is also very protective of Betty when it comes to “potential suitors” like Nicholas or Armando
	Sam Concepcion as Andrew Pengson – At first glance, you’d think that he’s just a happy-go-lucky kid who’s only out for some fun and excitement. But in truth, he’s a loving son who always wants the best for the Pengson family
	Wendy Valdez as Patricia Suarez – She happens to be Daniella’s accomplice in destroying Armando’s reputation and career as President of the company. As a rival secretary of Betty, she always creates devious schemes to get rid of her so she can freely execute her and Daniella’s hate campaign against Armando
	Joem Bascon as Mario Collantes – Despite his bad influence towards Armando when it comes to women, he nevertheless remains a loyal friend to him. As the VP for Creatives, Mario, he closely works with Hugo and Randy for their various events and ad campaigns.
	Thou Reyes as Hugo Bosini – Because he is a creative genius, he gets away with his annoying sarcasm when talking to the bigwigs including Armando’s father, Roberto. He’s a perfectionist who always wants the best out of every ad campaign that he makes. Yet despite his aversion to ugly people like Betty, he can also be nice when he wants to