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THUMBNAIL-MEDICAL

Agence France-Presse

<p>PARIS, France - A weight loss drug has been found to be broadly safe and effective for children under 12 with obesity, according to a small study on Wednesday that was cautiously welcomed by outside experts.</p><p>A new class of weight loss drugs called GLP-1 agonists have become hugely popular across the world in the last couple of years, sparking stock shortages and widespread off-label use despite steep prices.</p><p>But little research has been conducted on how these new drugs work on young children.</p><div><a href="https://news.abs-cbn.com/lifestyle/2024/5/22/use-of-weight-loss-drugs-soars-among-us-kids-and-young-adults-334" id="isPasted">Use of weight-loss drugs soars among US kids and young adults</a></div><div><a href="https://news.abs-cbn.com/spotlight/12/04/23/the-new-generation-of-weight-loss-drugs" id="isPasted">The new generation of weight-loss drugs</a></div><p>Obesity in children and adolescents has quadrupled since 1990, according to the World Health Organization. Yet there are no regularly prescribed drugs which treat obesity in children.</p><p>The study looked at an older GLP-1 agonist called liraglutide, sold under the brand name Saxenda by Danish pharmaceutical giant Novo Nordisk, which also makes the blockbuster semaglutide drugs Ozempic and Wegovy.</p><p>The US-based phase 3 trial, which was funded by Novo Nordisk, was the first to investigate liraglutide&#x27;s effect on under 12s.</p><p>It involved 82 children aged six to 12 with obesity, some of whom were randomly assigned a daily injection of liraglutide, while others received a placebo. The children were also encouraged to exercise and eat healthily.</p><p>After a little over a year, 46 percent of the children receiving the drug saw their body mass index (BMI) shrink by at least five percent, according to the study.</p><p>Only nine percent of the placebo group had such a reduction in BMI, which also takes into account height and was used because children at these ages grow quickly.</p><p>Some children taking the drug also reported side effects such as vomiting and nausea, which was in line with those experienced by adults, the researchers said.</p><p>Lead study author Claudia Fox of the University of Minnesota said that kids living with obesity are currently told to just &quot;try harder with diet and exercise&quot;.</p><p>But these findings raise hopes that a drug could one day help these children &quot;live healthier, more productive lives,&quot; she said in a statement.</p><div><a href="https://news.abs-cbn.com/lifestyle/2024/3/1/more-than-one-billion-now-afflicted-by-obesity-lancet-922" id="isPasted">More than one billion now afflicted by obesity: Lancet</a></div><div><a href="https://news.abs-cbn.com/news/11/14/22/more-filipinos-became-obese-during-pandemic-dost" id="isPasted">Obesity rates in PH rise during COVID-19 pandemic - DOST</a></div><div><strong>- Stunted growth fear -</strong></div><p>Stephen Burgess, a statistician at the University of Cambridge not involved in the research, said the study showed that drugs could &quot;help change the trajectory of weight gain in young children&quot;.</p><p>&quot;While receiving weight loss injections is clearly not the ideal solution to childhood obesity, reductions in body mass index for trial participants were sustained even beyond the duration of the treatment course,&quot; he told AFP.</p><p>Simon Cork, a researcher at the UK&#x27;s Anglia Ruskin University, said that &quot;the evidence that liraglutide is both safe and effective in children is positive&quot;.</p><p>But one concern about children taking weight loss drugs such as GLP-1 agonists which work by suppressing appetite is that this could risk stunting growth, he warned.</p><p>The new study showed no evidence this had occurred.</p><p>But Cork said that &quot;further studies over longer time periods will need to be undertaken to ensure that appetite suppression in these children does not have unforeseen negative consequences later in their development&quot;.</p><p>The study was presented at the European Association for the Study of Diabetes being held in Madrid, and was also published in the New England Journal of Medicine.</p><p>dl/giv</p><p>© Agence France-Presse</p><div><br/></div><div><ivs-player data-ivs-key="e8c22c015ca9eafa76f1e3edfa03c603" data-ivs-spid="3001339" data-ivs-vid="2492802"></ivs-player> <script src="https://player.ivideosmart.com/ivsplayer/v4/dist/js/loader.js"></script></div>

<p>A weight loss drug has been found to be broadly safe and effective for children under 12 with obesity, according to a small study on Wednesday that was cautiously welcomed by outside experts.</p>

A weight loss drug has been found to be broadly safe and effective for children under 12 with obesity, according to a small study on Wednesday that was cautiously welcomed by outside experts.

Weight loss drug safe, effective for under-12 kids: study

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Weight loss drug safe, effective for under-12 kids: study

Agence France-Presse

Published September 11, 2024 09:53 AM PHT

Read More:

health

childhood obesity

weight loss

weight loss drug

liraglutide

GLP-1

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