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Malaria drug touted by Trump fails to prevent COVID-19 in high profile study

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Michael Erman, Reuters

<div class="embed-wrap"><figure data-feedback="fb:likes,fb:comments"><img src="https://sa.kapamilya.com/absnews/abscbnnews/media/2020/reuters/06/04/20200603-health-coronavirus-hydroxychloroquine.jpg"/><figcaption>The drug hydroxychloroquine, pushed by US President Donald Trump and others in recent months as a possible treatment to people infected with the coronavirus disease (COVID-19), is displayed by a pharmacist at the Rock Canyon Pharmacy in Provo, Utah, US, May 27, 2020. George Frey, Reuters/file</figcaption></figure></div>The malaria drug promoted by US President Donald Trump as a treatment for COVID-19 was ineffective in preventing infection in people exposed to the coronavirus, according to a widely anticipated clinical trial released on Wednesday.The new trial found no serious side effects or heart problems from use of hydroxychloroquine.Vocal support from Trump kicked off a heated debate and raised expectations for the decades-old drug that could be a cheap and widely available tool in fighting the pandemic that has infected more than 6.4 million<ul class="op-related-articles">	<li><a href="https://news.abs-cbn.com/overseas/06/02/20/hydroxychloroquine-a-drug-dividing-the-world">Hydroxychloroquine: a drug dividing the world</a></li>	<li><a href="https://news.abs-cbn.com/overseas/06/04/20/who-resumes-trials-on-controversial-drug-vs-coronavirus">WHO resumes trials on controversial drug vs coronavirus</a></li></ul>In the first major study comparing hydroxychloroquine to a placebo to gauge its effect against the new coronavirus, University of Minnesota researchers tested 821 people who had recently been exposed to the virus or lived in a high-risk household.It found 11.8 percent of subjects given hydroxychloroquine developed symptoms compatible with COVID-19, compared with 14.3 percent who got a placebo. That difference was not statistically significant, meaning the drug was no better than placebo.&quot;Our data is pretty clear that for post exposure, this does not really work,&quot; said Dr. David Boulware, the trial&#x27;s lead researcher and an infectious disease physician at the University of Minnesota.Several trials of the drug have been stopped over concerns about its safety for treating COVID-19 that were raised by health regulators and previous less rigorous studies.&quot;I think both sides - one side who is saying &#x27;this is a dangerous drug&#x27; and the other side that says &#x27;this works&#x27; - neither is correct,&quot; said Boulware.The results were also published in the New England Journal of Medicine.In March, Trump said hydroxychloroquine used in combination with the antibiotic azithromycin had &quot;a real chance to be one of the biggest game changers in the history of medicine&quot; with little evidence to back up that claim. He later said he took the drugs preventively after two people who worked at the White House were diagnosed with COVID-19, the illness caused by the novel coronavirus.Hydroxychloroquine - which has anti-inflammatory and antiviral properties - inhibited the virus in laboratory experiments. But these type of human trials are needed to definitively demonstrate whether the drug&#x27;s benefits, if any, outweigh the risks when compared with a placebo.Proponents of the drug as a COVID-19 treatment argue it may need to be administered at an earlier stage in the disease to be effective. Others have suggested that it needs to be used in combination with the mineral zinc, which can help boost the immune system.More than 20 percent of the trial subjects also took zinc, which had no significant effect.The US Food and Drug Administration cautioned in late April against the use of hydroxychloroquine in patients with heart disease due to an increased risk of dangerous cardiac rhythm problems.Boulware said his trial had fewer participants than initially planned because of difficulty enrolling new subjects after the FDA&#x27;s warning.On Tuesday, the British medical journal the Lancet said it had concerns about data behind an influential article that found hydroxychloroquine increased the risk of death in COVID-19 patients, a conclusion that undercut scientific interest in the medicine.Boulware was one of the signatories of an open letter from doctors that called attention to potential problems with that study.Some European governments banned hydroxychloroquine for COVID-19 patients, and U.S. hospitals have significantly cut back its use.In the University of Minnesota trial, 40 percent of the those who took hydroxychloroquine reported less serious side effects like nausea and abdominal discomfort versus 17 percent in the placebo group.Results of another University of Minnesota placebo-controlled trial testing hydroxychloroquine as a coronavirus treatment rather than to prevent infection is expected soon.

The malaria drug promoted by US President Donald Trump as a treatment for COVID-19 was ineffective in preventing infection in people exposed to the coronavirus, according to a widely anticipated clinical trial released on Wednesday.

The malaria drug promoted by US President Donald Trump as a treatment for COVID-19 was ineffective in preventing infection in people exposed to the coronavirus, according to a widely anticipated clinical trial released on Wednesday.

Malaria drug touted by Trump fails to prevent COVID-19 in high profile study

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Malaria drug touted by Trump fails to prevent COVID-19 in high profile study

Michael Erman,

Reuters

Published June 04, 2020 07:50 AM PHT

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ANC

US

US COVID-19

Donald Trump

hydroxychloroquine

anti-malaria drug

COVID-19

coronavirus

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