“Walang Iwanan” follows the story of Jose, played by Louise Abuel, who is the son of Anita, played by Roxanne Guinoo. His stepfather Kamlon, played by Jhong Hilario spares the young Jose the affection that a father gives a child since the boy was the fruit of Anita’s past relationship.

Micko Laurente plays Boy, the first-born of Anita and Kamlon, who will make life hard for Jose to be friends with his other siblings. His three other siblings include Criscencio (played by Jon Michael), Maribel (Carla Cruz) and Michael (Raikko Mateo).

While his stepfather doesn’t recognize him, and his step-brothers and sister alienate him, Jose finds solace in his grandmothers, with whom he grew up with, Ina and Ebe, who shower the boy with the love that he’s missing out on. Their love prepared Jose to be strong enough to be part of a true family. He grows up to be a fine-mannered boy who just wants a family that loves one another.
Trouble happens when the kids find their parents missing one morning and had to fend off for themselves. Jose and Boy try to work their differences out for the sake of their siblings as they hope to find out what happened to their parents and be together once again as a family.

Other members of the cast are John Estrada, Beauty Gonzales, and Nicco Manalo.